Following the introduction of the anti-vascular endothelial growth factor (VEGF) therapies over a decade ago, the wet age-related macular degeneration (AMD) market has been dominated by three therapies—Roche/Genentech/Novartis’s Lucentis, approved for wet AMD, Roche/Genentech/Chugai’s Avastin, approved for cancer but commonly compounded and used off-label for wet AMD, and, most recently, Regeneron/Bayer HealthCare/Santen’s Eylea, which has experienced strong and continued uptake at the expense of the other drugs within this class.
Although the majority of AMD patients are diagnosed with the dry form of AMD, management of this disease type is limited to minimally effective vitamin formulations because no prescription pharmacotherapies are approved for this large and underserved subpopulation. However, the pipeline features a growing number of novel agents targeting the advanced form of dry AMD (i.e., geographic atrophy [GA]), as well as therapies for wet AMD.
This report will answer the following key questions:
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